Fertility and sterility · 2001
Screening for mutations of the androgen receptor gene in patients with isolated cryptorchidism.
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Suzuki Y, Sasagawa I, Ashida J, Nakada T, Muroya K, Ogata T
Аннотация
OBJECTIVE: To evaluate the occurrence of mutations of androgen receptor (AR) gene in patients with isolated cryptorchidism.
DESIGN: Controlled clinical study.
SETTING: Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan.
PATIENT(S): Patients with isolated cryptorchidism (n = 48) and a control group of men with normal phenotype (n = 20).
INTERVENTION(S): Blood (lymphocyte DNA).
MAIN OUTCOME MEASURE(S): Screening of the AR gene in exons 1-8 using single-strand conformational polymorphism analysis.
RESULT(S): No abnormal band patterns were detected in patients with cryptorchidism or in control subjects within the eight exons of the AR gene.
CONCLUSION(S): AR gene alterations appear to be an unlikely cause of isolated cryptorchidism.
DESIGN: Controlled clinical study.
SETTING: Yamagata University Hospital, Yamagata and Tokyo Electric Power Company Hospital, Tokyo, Japan.
PATIENT(S): Patients with isolated cryptorchidism (n = 48) and a control group of men with normal phenotype (n = 20).
INTERVENTION(S): Blood (lymphocyte DNA).
MAIN OUTCOME MEASURE(S): Screening of the AR gene in exons 1-8 using single-strand conformational polymorphism analysis.
RESULT(S): No abnormal band patterns were detected in patients with cryptorchidism or in control subjects within the eight exons of the AR gene.
CONCLUSION(S): AR gene alterations appear to be an unlikely cause of isolated cryptorchidism.