Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group.
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Abé Christoph, Ching Christopher R K, Liberg Benny, Lebedev Alexander V, Agartz Ingrid, Akudjedu Theophilus N, Alda Martin, Alnæs Dag, Alonso-Lana Silvia, Benedetti Francesco, Berk Michael, Bøen Erlend, Bonnin Caterina Del Mar, Breuer Fabian, Brosch Katharina, Brouwer Rachel M, Canales-Rodríguez Erick J, Cannon Dara M, Chye Yann, Dahl Andreas, Dandash Orwa, Dannlowski Udo, Dohm Katharina, Elvsåshagen Torbjørn, Fisch Lukas, Fullerton Janice M, Goikolea Jose M, Grotegerd Dominik, Haatveit Beathe, Hahn Tim, Hajek Tomas, Heindel Walter, Ingvar Martin, Sim Kang, Kircher Tilo T J, Lenroot Rhoshel K, Malt Ulrik F, McDonald Colm, McWhinney Sean R, Melle Ingrid, Meller Tina, Melloni Elisa M T, Mitchell Philip B, Nabulsi Leila, Nenadić Igor, Opel Nils, Overs Bronwyn J, Panicalli Francesco, Pfarr Julia-Katharina, Poletti Sara, Pomarol-Clotet Edith, Radua Joaquim, Repple Jonathan, Ringwald Kai G, Roberts Gloria, Rodriguez-Cano Elena, Salvador Raymond, Sarink Kelvin, Sarró Salvador, Schmitt Simon, Stein Frederike, Suo Chao, Thomopoulos Sophia I, Tronchin Giulia, Vieta Eduard, Westlye Lars T, White Adam G, Yatham Lakshmi N, Zak Nathalia, Thompson Paul M, Andreassen Ole A, Landén Mikael, ENIGMA Bipolar Disorder Working Group
Аннотация
METHODS: Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and female participants, aged 40 ± 17 years, underwent MRI at 2 time points. Cortical thickness, surface area, and subcortical volumes were estimated using FreeSurfer. Annualized change rates for each imaging phenotype were compared between patients with BD and healthy control subjects. Within patients, we related brain change rates to the number of mood episodes between time points and tested for effects of demographic and clinical variables.
RESULTS: Compared with healthy control subjects, patients with BD showed faster enlargement of ventricular volumes and slower thinning of the fusiform and parahippocampal cortex (0.18 <d < 0.22). More (hypo)manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex.
CONCLUSIONS: In the hitherto largest longitudinal MRI study on BD, we did not detect accelerated cortical thinning but noted faster ventricular enlargements in BD. However, abnormal frontocortical thinning was observed in association with frequent manic episodes. Our study yields insights into disease progression in BD and highlights the importance of mania prevention in BD treatment.