Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium.
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Ivanov Iliyan, Boedhoe Premika S W, Abe Yoshinari, Alonso Pino, Ameis Stephanie H, Arnold Paul D, Balachander Srinivas, Baker Justin T, Banaj Nerisa, Bargalló Nuria, Batistuzzo Marcelo C, Benedetti Francesco, Beucke Jan C, Bollettini Irene, Brem Silvia, Brennan Brian P, Buitelaar Jan, Calvo Rosa, Cheng Yuqi, Cho Kang Ik K, Dallaspezia Sara, Denys Damiaan, Diniz Juliana B, Ely Benjamin A, Feusner Jamie D, Ferreira Sónia, Fitzgerald Kate D, Fontaine Martine, Gruner Patricia, Hanna Gregory L, Hirano Yoshiyuki, Hoexter Marcelo Q, Huyser Chaim, Ikari Keisuke, James Anthony, Jaspers-Fayer Fern, Jiang Hongyan, Kathmann Norbert, Kaufmann Christian, Kim Minah, Koch Kathrin, Kwon Jun Soo, Lázaro Luisa, Liu Yanni, Lochner Christine, Marsh Rachel, Martínez-Zalacaín Ignacio, Mataix-Cols David, Menchón José M, Minuzzi Luciano, Morer Astrid, Morgado Pedro, Nakagawa Akiko, Nakamae Takashi, Nakao Tomohiro, Narayanaswamy Janardhanan C, Nurmi Erika L, Oh Sanghoon, Perriello Chris, Piacentini John C, Picó-Pérez Maria, Piras Fabrizio, Piras Federica, Reddy Y C Janardhan, Manrique Daniela Rodriguez, Sakai Yuki, Shimizu Eiji, Simpson H Blair, Soreni Noam, Soriano-Mas Carles, Spalletta Gianfranco, Stern Emily R, Stevens Michael C, Stewart S Evelyn, Szeszko Philip R, Tolin David F, van Rooij Daan, Veltman Dick J, van der Werf Ysbrand D, van Wingen Guido A, Venkatasubramanian Ganesan, Walitza Susanne, Wang Zhen, Watanabe Anri, Wolters Lidewij H, Xu Xiufeng, Yun Je-Yeon, Zarei Mojtaba, Zhang Fengrui, Zhao Qing, Jahanshad Neda, Thomopoulos Sophia I, Thompson Paul M, Stein Dan J, van den Heuvel Odile A, O'Neill Joseph, ENIGMA-OCD Working Group
Аннотация
METHODS: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6-65) was divided into six successive 6-10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients.
RESULTS: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6-13 and adults aged 50-65 with OCD taking SRIs (Cohen's d = -0.24 to -0.74). Volumes of putamen, pallidum (d = 0.18-0.40), and ventricles (d = 0.31-0.66) were greater in patients aged 20-29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = -0.27 to -1.31).
CONCLUSIONS: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20-29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.