Voprosy virusologii · 2010
[Characterization of vaccine polioviruses isolated in the closed pediatric collective bodies (children's homes)].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
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Romanenkova N I, Bichurina M A, Rozaeva N R
Аннотация
Examination of 281 healthy vaccinees from 6 children's homes could isolate 37 vaccine polioviruses. The detection rate for polioviruses in the children's homes, in which there were children born to HIV-positive mothers, was significantly higher than that in other children's homes. These children's homes showed the longest poliovirus excretion after vaccination. The RFLP analysis showed that 40% of the strains being examined were intertypic recombinant strains. The sequence analysis demonstrated that about 30% of the strains under study had a small number of nucleotide substitutions in the VP3-VP1 genomic region. The study revealed a correlation between the dynamics of poliovirus excretion after oral vaccination and the kinetics of formation of recombinant poliovirus strains.