The effects of spinosad on antioxidant system and cognitive performance of mice.

INTRODUCTION

There are few studies examining the effect of spinosad on cognitive functions in the literature.

METHODS

In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance.

RESULTS

In the open field test, we observed a significant decrease (p < .05) in the total distance travelled and the time spent in the central area in all subjects who underwent spinosad. In the novel object recognition test, we observed decreases in the time spent with new and old objects. From the biochemical point of view, while BDNF and NGF levels were significantly lower in the spinosad applied group (p < .05), there was no difference in GPx and SOD levels (p > .05).

CONCLUSIONS

These results show that spinosad disrupts cognitive functions at the doses we used in our study and this negative effect may be related to the decrease in neurotrophic factors.