BMJ paediatrics open · 2022
Pubertal stage, sex and behaviour in neurodevelopmental disorders versus typical development: a cross-sectional study.
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Penner Melanie, Dupuis Annie, Arnold Paul, Ayub Muhammad, Crosbie Jennifer, Georgiades Stelios, Kelley Elizabeth, Nicolson Robert, Schachar Russell, Anagnostou Evdokia
Аннотация
OBJECTIVE: To determine the association between pubertal stage, sex and behavioural profile across and within neurodevelopmental disorders (NDDs) compared with typically developing (TD) youth.
METHODS: This was a cross-sectional study from the Province of Ontario Neurodevelopmental Disorders network, including children/youth with various NDDs and TD controls. Caregivers completed the Child Behavior Checklist (CBCL). Participants were grouped into three puberty stages: prepuberty (Tanner stage 1), early puberty (Tanner stages 2-3) and late puberty (Tanner stages 4-5). The association between pubertal stage and CBCL scores was assessed controlling for sex and diagnosis.
RESULTS: The analysis included 1043 participants (male=733; 70.3%). A three-way interaction between pubertal status, sex and diagnosis was not significant for internalising or externalising behaviour. Diagnosis was significantly associated with CBCL scores for both internalising (p<0.0001) and externalising (p<0.0001) behaviours, with lower scores for TD children than for NDD groups. Late pubertal females showed higher levels of internalising behaviour compared with prepubertal females (p=0.001); males showed no differences. Early pubertal males showed lower levels of externalising behaviour compared with prepubertal males (p=0.01); early pubertal females trended towards higher levels compared with prepubertal females (p=0.051).
CONCLUSIONS: Internalising/externalising patterns of behaviours across pubertal stages did not differ based on diagnosis. Pubertal females are at higher risk for internalising behaviours.
METHODS: This was a cross-sectional study from the Province of Ontario Neurodevelopmental Disorders network, including children/youth with various NDDs and TD controls. Caregivers completed the Child Behavior Checklist (CBCL). Participants were grouped into three puberty stages: prepuberty (Tanner stage 1), early puberty (Tanner stages 2-3) and late puberty (Tanner stages 4-5). The association between pubertal stage and CBCL scores was assessed controlling for sex and diagnosis.
RESULTS: The analysis included 1043 participants (male=733; 70.3%). A three-way interaction between pubertal status, sex and diagnosis was not significant for internalising or externalising behaviour. Diagnosis was significantly associated with CBCL scores for both internalising (p<0.0001) and externalising (p<0.0001) behaviours, with lower scores for TD children than for NDD groups. Late pubertal females showed higher levels of internalising behaviour compared with prepubertal females (p=0.001); males showed no differences. Early pubertal males showed lower levels of externalising behaviour compared with prepubertal males (p=0.01); early pubertal females trended towards higher levels compared with prepubertal females (p=0.051).
CONCLUSIONS: Internalising/externalising patterns of behaviours across pubertal stages did not differ based on diagnosis. Pubertal females are at higher risk for internalising behaviours.