Nanomedicine (London, England) · 2010
Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mejías Raquel, Pérez-Yagüe Sonia, Roca Alejandro G, Pérez Nicolás, Villanueva Angeles, Cañete Magdalena, Mañes Santos, Ruiz-Cabello Jesús, Benito Marina, Labarta Amilcar, Batlle Xavier, Veintemillas-Verdaguer Sabino, Morales M Puerto, Barber Domingo F, Serna Carlos J
Аннотация
BACKGROUND & AIM: Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures.
MATERIAL & METHOD: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity.
RESULTS: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
MATERIAL & METHOD: We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity.
RESULTS: In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.