Fertility and sterility · 1996
Successful twin pregnancy in homozygous beta-thalassemia after ovulation induction with growth hormone and gonadotropins.
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Surbek D, Koller A, Pavic N
Аннотация
OBJECTIVE: To describe infertility treatment and pregnancy outcome in a patient with transfusion-dependent beta-thalassemia major and hypopituitarism.
DESIGN: Case report.
SETTING: University-affiliated infertility clinic.
PATIENT: Twenty-four-year-old infertile patient with homozygous beta-thalassemia.
INTERVENTION: Co-treatment with GH and gonadotropins.
RESULTS: Ovulation induction with clomiphene citrate or gonadotropins alone was unsuccessful. Combined treatment with hMG, hCG, and recombinant human GH followed by intrauterine insemination resulted in a viable twin pregnancy.
CONCLUSION: Human GH as an adjunct to hMG and hCG seems to be a sensible approach in the treatment of infertile homozygous beta-thalassemic patients among which very few pregnancies are reported.
DESIGN: Case report.
SETTING: University-affiliated infertility clinic.
PATIENT: Twenty-four-year-old infertile patient with homozygous beta-thalassemia.
INTERVENTION: Co-treatment with GH and gonadotropins.
RESULTS: Ovulation induction with clomiphene citrate or gonadotropins alone was unsuccessful. Combined treatment with hMG, hCG, and recombinant human GH followed by intrauterine insemination resulted in a viable twin pregnancy.
CONCLUSION: Human GH as an adjunct to hMG and hCG seems to be a sensible approach in the treatment of infertile homozygous beta-thalassemic patients among which very few pregnancies are reported.