Antibiotic sandwich patch for ventricular septal defect complicated by endocarditis.

Infective endocarditis in patients with ventricular septal defects can prove life threatening due to acute heart failure or septic embolization. Persistent postoperative risk is bacterial colonization of prosthetic material. We designed the Antibiotic Sandwich Patch to reduce this risk, using a double layer of autologous pericardium containing antibiotic powder. Five patients were managed with this technique for closure of ventricular septal defects complicated by acute infective endocarditis. No colonization of the patches occurred after a median follow up of 1.5 years. This technique reduced the risk of bacterial colonization of the antibiotic sandwich patch, offering an additional surgical option.