Human papillomavirus genotypes among females in Mexico: a study from the Mexican institute for social security.
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Salcedo Mauricio, Pina-Sanchez Patricia, Vallejo-Ruiz Veronica, Monroy-Garcia Alberto, Aguilar-Lemarroy Adriana, Cortes-Gutierrez Elva I, Santos-Lopez Gerardo, Montoya-Fuentes Hector, Grijalva Renan, Madrid-Marina Vicente, Apresa-Garcia Teresa, Hernandez Dulce M, Jave-Suarez Luis F, Romero Pablo, Poot Albros, Salgado Eduardo, Ramos-Gonzalez Patricia, Gonzalez-Hernandez Rigoberto, Canton Juan C, Jimenez-Aranda Lucio, Parra-Melquiadez Miriam, Paniagua Lucero, Mendoza Monica, Arreola Hugo, Villegas Vanesa, Torres-Poveda Kirvis, Bahena-Roman Margarita, Gonzalez-Yebra Beatriz, Taniguchi Keiko, Rodea Carlos, Mantilla-Morales Alejandra, Mora-Garcia Maria L, Velazquez-Velazquez Cindy K, Cordova-Uscanga Candelaria, Peralta Raul, Lopez-Romero Ricardo, Marrero Daniel, Bandala Cindy, Reyes-Leyva Julio, Furuya Maria E, Almeida Eduardo, Galvan Maria E, Grijalva Israel
Аннотация
MATERIALS AND METHODS: DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC.
RESULTS: Overall HPV prevalence was 67.1%. A total of 40 HPV types were found; HPV16 was detected in 39.4% of the HPV-positive samples followed by HPV18 at 7.5%, HPV31 at 7.1%, HPV59 at 4.9%, and HPV58 at 3.2%. HPV16 presented the highest prevalence both in women with altered or normal cytology and HPV 18 presented a minor prevalence as reported worldwide. The prevalence ratio (PR) was calculated for the HPV types. The analysis of PR showed that HPV16 presents the highest association with CC, HPV 31, -33, -45, -52 and -58 also demonstrating a high association.
CONCLUSIONS: The most prevalent HPV types in cervical cancer samples were -16, -18, -31, but it is important to note that we obtained a minor prevalence of HPV18 as reported worldwide, and that HPV58 and -52 also were genotypes with an important prevalence in CC samples. Determination of HPV genotypes is very important in order to evaluate the impact of vaccine introduction and future cervical cancer prevention strategies.