Chemical constituents from the fruiting bodies of Lanmaoa asiatica and their anti-inflammatory activity.

Four new compounds, dimethyl 3,5-bis(4-hydroxyphenyl)-1H-pyrrole-2,4-dicarboxylate (1), dimethyl 3,5-bis(4-hydroxyphenyl)-1H-furan-2,4-dicarboxylate (2), 5α-hydroxy-6β-methoxy-ergosta-7,22E-dien-3-one (3), and 6-methoxy-strophasterol E (4), together with sixteen known compounds (5-20), were isolated from the fruiting bodies of Lanmaoa asiatica. The structures of new compounds were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Among them, compounds 2, 4, 7, and 9 exhibited anti-inflammatory activity by suppressing NO production in lipopolysaccharide-stimulated RAW264.7 macrophages with IC50 values ranging from 20.3 to 47.3 μM.