Vitamin D deficiency in a European inflammatory bowel disease inception cohort: an Epi-IBD study.
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Chetcuti Zammit Stefania, Ellul Pierre, Girardin Giulia, Valpiani Daniela, Nielsen Kári R, Olsen Jóngerð, Goldis Adrian, Lazar Daniela, Shonová Olga, Nováková Marie, Sebastian Shaji, Whitehead Emma, Carmona Amalia, Martinez-Cadilla Jesus, Dahlerup Jens F, Kievit Adriana L H, Thorsgaard Niels, Katsanos Konstantinos H, Christodoulou Dimitrios K, Magro Fernando, Salupere Riina, Pedersen Natalia, Kjeldsen Jens, Carlsen Katrine, Ioannis Kaimaklioti, Bergemalm Daniel, Halfvarson Jonas, Duricova Dana, Bortlik Martin, Collin Pekka, Oksanen Pia, Kiudelis Gediminas, Kupcinskas Limas, Kudsk Karen, Andersen Vibeke, O'Morain Colm, Bailey Yvonne, Doron Schwartz, Shmuel Odes, Almer Sven, Arebi Naila, Misra Ravi, Čuković-Čavka Silvija, Brinar Marko, Munkholm Pia, Vegh Zsuzsanna, Burisch Johan
Аннотация
MATERIALS AND METHODS: Patients diagnosed with IBD between 2010 and 2011 were recruited. Demographic data and serum vitamin D levels were collected. Variance of vitamin D level was then assessed across different treatment groups, disease phenotype, disease activity and quality of life scores.
RESULTS: A total of 238 (55.9% male) patients were included. Overall, 79% of the patients had either insufficient or deficient levels of vitamin D at diagnosis. Patients needing corticosteroid treatment at 1 year had significantly lower vitamin D levels at diagnosis (median 36.0 nmol/l) (P=0.035). Harvey-Bradshaw Index (P=0.0001) and Simple Clinical Colitis Activity Index scores (P=0.0001) were significantly lower in patients with higher vitamin D level. Serum vitamin D level correlated significantly with SIBQ score (P=0.0001) and with multiple components of SF12. Smokers at diagnosis had the lowest vitamin D levels (vitamin D: 34 nmol/l; P=0.053).
CONCLUSION: This study demonstrates the high prevalence of low vitamin D levels in treatment-naive European IBD populations. Furthermore, it demonstrates the presence of low vitamin D levels in patients with IBD who smoke.