Leiomyosarcoma After Liver Transplantation Is Unrelated to Epstein-Barr Virus: A Case Report.

BACKGROUND

De novo malignancy is a severe complication after liver transplantation (LT), but de novo leiomyosarcoma is extremely rare.

METHODS

We reported de novo leiomyosarcoma occurring after LT. The patient's status for Epstein-Barr virus was negative. The donor was a 21-year-old man with a central nervous system malignancy who underwent surgery. Three months later brain death occurred and his organs were donated.

RESULTS

Leiomyosarcoma in the recipient was detected shortly after LT. It progressed after minimization of immunosuppression and apatinib therapy, and the patient died of cachexia 17 months after LT.

CONCLUSIONS

De novo leiomyosarcoma is a rare but serious event after LT, needing comprehensive management.