Poliovaccines: lessons learnt and forgotten.

At the beginning of the twentieth century, poliomyelitis presented a scientific and medical challenge of a complexity similar to that of AIDS now. Research on polio, mainly in the US, gradually became focussed to solving basic questions, but was held up by the lack of suitable laboratory techniques. The financing of the research and the wide range of basic topics funded were the model for later medical science. The problem of polio, at least in the wealthier temperate countries, has been solved by the use of vaccines. Many fundamental questions about the mechanism of the disease remained unsolved and this lack of knowledge has contributed to many unfortunate accidents. The history of polio has many lessons for AIDS researchers.