Journal of ethnopharmacology · 2010
Antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Pádua Bruno da Cruz, Silva Lucas Dornela, Rossoni Júnior Joamyr Victor, Humberto Jorge Luiz, Chaves Míriam Martins, Silva Marcelo Eustáquio, Pedrosa Maria Lucia, Costa Daniela Caldeira
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species.
AIM OF THE STUDY: The aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models.
MATERIAL AND METHODS: In the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0 microg/mL. In the in vivo assay, male rats were first treated with crude extract 600 mg/kg body weight of Baccharis trimera or with 50 mg/kg body weight of quercetin (reference substance) and then treated with 835 mg/kg of acetaminophen (APAP) after 24 h.
RESULTS: The hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect.
CONCLUSION: The results of this study confirm the antioxidant effect of Baccharis trimera.
AIM OF THE STUDY: The aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models.
MATERIAL AND METHODS: In the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0 microg/mL. In the in vivo assay, male rats were first treated with crude extract 600 mg/kg body weight of Baccharis trimera or with 50 mg/kg body weight of quercetin (reference substance) and then treated with 835 mg/kg of acetaminophen (APAP) after 24 h.
RESULTS: The hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect.
CONCLUSION: The results of this study confirm the antioxidant effect of Baccharis trimera.