Birth defects research · 2017
Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population.
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Bagheri Fahimeh, Ebadifar Asghar, Khorram Khorshid Hamid Reza, Kamali Koorosh
Аннотация
BACKGROUND: The aim of this study is to evaluate the association of TGFA TaqI polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population.
METHODS: In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p-value of <0.05 was considered statistically significant.
RESULTS: For the TGFA TaqI polymorphism, the distributions of genotypes in the NSCLP (p = 0.810) and control group (p = 0.422) were in Hardy-Weinberg equilibrium. There was no statistically significant difference in the genotype distribution (p = 0.059) and allele frequency (p = 0.065) of the TGFA TaqI polymorphism in the NSCLP and control groups.
CONCLUSION: TGFA TaqI polymorphism was not associated with the risk of NSCLP in Iranian children. Birth Defects Research 109:1386-1389, 2017.© 2017 Wiley Periodicals, Inc.
METHODS: In this case-control study, 113 children with NSCLP and 209 controls were included. Genotyping of the TaqI polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p-value of <0.05 was considered statistically significant.
RESULTS: For the TGFA TaqI polymorphism, the distributions of genotypes in the NSCLP (p = 0.810) and control group (p = 0.422) were in Hardy-Weinberg equilibrium. There was no statistically significant difference in the genotype distribution (p = 0.059) and allele frequency (p = 0.065) of the TGFA TaqI polymorphism in the NSCLP and control groups.
CONCLUSION: TGFA TaqI polymorphism was not associated with the risk of NSCLP in Iranian children. Birth Defects Research 109:1386-1389, 2017.© 2017 Wiley Periodicals, Inc.
Предметные рубрики MeSH
AdolescentAdultCase-Control StudiesChildChild, PreschoolCleft LipCleft PalateDeoxyribonucleases, Type II Site-SpecificFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansInfantInfant, NewbornIranMalePolymorphism, GeneticPolymorphism, Restriction Fragment LengthRisk FactorsTransforming Growth Factor alphaYoung Adult