Медицинская библиотека · Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022

Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.

Sun Delin, Rakesh Gopalkumar, Clarke-Rubright Emily K, Haswell Courtney C, Logue Mark W, O'Leary Erin N, Cotton Andrew S, Xie Hong, Dennis Emily L, Jahanshad Neda, Salminen Lauren E, Thomopoulos Sophia I, Rashid Faisal M, Ching Christopher R K, Koch Saskia B J, Frijling Jessie L, Nawijn Laura, van Zuiden Mirjam, Zhu Xi, Suarez-Jimenez Benjamin, Sierk Anika, Walter Henrik, Manthey Antje, Stevens Jennifer S, Fani Negar, van Rooij Sanne J H, Stein Murray B, Bomyea Jessica, Koerte Inga, Choi Kyle, van der Werff Steven J A, Vermeiren Robert R J M, Herzog Julia I, Lebois Lauren A M, Baker Justin T, Ressler Kerry J, Olson Elizabeth A, Straube Thomas, Korgaonkar Mayuresh S, Andrew Elpiniki, Zhu Ye, Li Gen, Ipser Jonathan, Hudson Anna R, Peverill Matthew, Sambrook Kelly, Gordon Evan, Baugh Lee A, Forster Gina, Simons Raluca M, Simons Jeffrey S, Magnotta Vincent A, Maron-Katz Adi, du Plessis Stefan, Disner Seth G, Davenport Nicholas D, Grupe Dan, Nitschke Jack B, deRoon-Cassini Terri A, Fitzgerald Jacklynn, Krystal John H, Levy Ifat, Olff Miranda, Veltman Dick J, Wang Li, Neria Yuval, De Bellis Michael D, Jovanovic Tanja, Daniels Judith K, Shenton Martha E, van de Wee Nic J A, Schmahl Christian, Kaufman Milissa L, Rosso Isabelle M, Sponheim Scott R, Hofmann David Bernd, Bryant Richard A, Fercho Kelene A, Stein Dan J, Mueller Sven C, Phan K Luan, McLaughlin Katie A, Davidson Richard J, Larson Christine, May Geoffrey, Nelson Steven M, Abdallah Chadi G, Gomaa Hassaan, Etkin Amit, Seedat Soraya, Harpaz-Rotem Ilan, Liberzon Israel, Wang Xin, Thompson Paul M, Morey Rajendra A

СтатьяМетаанализПоддержка исследования: вне правительства СШАПоддержка NIH: внешняя программаПоддержка правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).

METHODS

Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2-148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks.

RESULTS

Patients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks.

CONCLUSIONS

Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD.

Для цитирования: Sun Delin, Rakesh Gopalkumar, Clarke-Rubright Emily K, Haswell Courtney C, Logue Mark W, O'Leary Erin N, Cotton Andrew S, Xie Hong, Dennis Emily L, Jahanshad Neda, Salminen Lauren E, Thomopoulos Sophia I, Rashid Faisal M, Ching Christopher R K, Koch Saskia B J, Frijling Jessie L, Nawijn Laura, van Zuiden Mirjam, Zhu Xi, Suarez-Jimenez Benjamin, Sierk Anika, Walter Henrik, Manthey Antje, Stevens Jennifer S, Fani Negar, van Rooij Sanne J H, Stein Murray B, Bomyea Jessica, Koerte Inga, Choi Kyle, van der Werff Steven J A, Vermeiren Robert R J M, Herzog Julia I, Lebois Lauren A M, Baker Justin T, Ressler Kerry J, Olson Elizabeth A, Straube Thomas, Korgaonkar Mayuresh S, Andrew Elpiniki, Zhu Ye, Li Gen, Ipser Jonathan, Hudson Anna R, Peverill Matthew, Sambrook Kelly, Gordon Evan, Baugh Lee A, Forster Gina, Simons Raluca M, Simons Jeffrey S, Magnotta Vincent A, Maron-Katz Adi, du Plessis Stefan, Disner Seth G, Davenport Nicholas D, Grupe Dan, Nitschke Jack B, deRoon-Cassini Terri A, Fitzgerald Jacklynn, Krystal John H, Levy Ifat, Olff Miranda, Veltman Dick J, Wang Li, Neria Yuval, De Bellis Michael D, Jovanovic Tanja, Daniels Judith K, Shenton Martha E, van de Wee Nic J A, Schmahl Christian, Kaufman Milissa L, Rosso Isabelle M, Sponheim Scott R, Hofmann David Bernd, Bryant Richard A, Fercho Kelene A, Stein Dan J, Mueller Sven C, Phan K Luan, McLaughlin Katie A, Davidson Richard J, Larson Christine, May Geoffrey, Nelson Steven M, Abdallah Chadi G, Gomaa Hassaan, Etkin Amit, Seedat Soraya, Harpaz-Rotem Ilan, Liberzon Israel, Wang Xin, Thompson Paul M, Morey Rajendra A. Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium.. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2022. DOI: 10.1016/j.bpsc.2022.02.008.

Предметные рубрики MeSH

Adolescent Adult Aged Aged, 80 and over Case-Control Studies Child Connectome Humans Magnetic Resonance Imaging Middle Aged Neuroimaging Stress Disorders, Post-Traumatic Young Adult

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