Chemistry & biodiversity · 2025
Anti-Neuroinflammatory Labdane Diterpenoids From the Rhizomes of Alpinia zerumbet.
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Wu Jinghui, Zhang Wenxin, Xu Jingwen, Wang Yihai, He Xiangjiu
Аннотация
Alpinia zerumbet, commonly known as shell ginger, is a plant of significant ornamental and medicinal value. In the present study, nine labdane-type diterpenoids, including four novel (1-4) and five known (5-9), were isolated and identified from the rhizomes of A. zerumbet. Anti-neuroinflammatory activities of the isolated labdane-type diterpenoids were evaluated in lipopolysaccharide (LPS)-stimulated microglia BV2 cells. Compounds 3, 5, 6, and 8 could significantly inhibit the production of nitric oxide (NO) in LPS-stimulated BV2 cells. Among them, the IC50 values of compounds 5 and 8 were 26.14 ± 1.62 and 17.29 ± 6.28 µM, which were lower than that of the positive control, minocycline (IC50 = 30.26 ± 1.99 µM).