Brain and language · 2014
Human speech- and reading-related genes display partially overlapping expression patterns in the marmoset brain.
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Kato Masaki, Okanoya Kazuo, Koike Taku, Sasaki Erika, Okano Hideyuki, Watanabe Shigeru, Iriki Atsushi
Аннотация
Language is a characteristic feature of human communication. Several familial language impairments have been identified, and candidate genes for language impairments already isolated. Studies comparing expression patterns of these genes in human brain are necessary to further understanding of these genes. However, it is difficult to examine gene expression in human brain. In this study, we used a non-human primate (common marmoset; Callithrix jacchus) as a biological model of the human brain to investigate expression patterns of human speech- and reading-related genes. Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed. We found the genes displayed overlapping expression patterns in the ocular, auditory, and motor systems. Our results enhance understanding of the molecular mechanisms underlying language impairments.
Предметные рубрики MeSH
Age FactorsAnimalsBrainBrain ChemistryCallithrixDisease Models, AnimalDyslexiaFemaleForkhead Transcription FactorsGene Expression ProfilingHumansIn Situ HybridizationLanguageLanguage DisordersMaleMembrane ProteinsMicrotubule-Associated ProteinsNerve Tissue ProteinsReadingReceptors, ImmunologicRepressor ProteinsSpeechSpeech DisordersRoundabout Proteins