[Influence of patient age and year of developing the disease on immunologic response to measles virus in subacute sclerosing panencephalitis (SSPE)].

Analyses were concerning 338 SSPE patients investigated in the years 1984-1989 from a group in which 305 persons were known regarding year of illness development and their age at the time of sample taking. The analysis has shown statistically significant decrease of antibodies against measles virus with increase of age of tested patients. At the same time, it was found that in persons who developed disease in 1983-1985 and in 1988, increase of mean value of antibodies against measles virus was evident during first 2-3 years from beginning of the SSPE. Comparison of mean values of antibodies against measles virus in age groups of SSPE patients and normal population, revealed existence of relation between these groups where source of antibodies constituted of a wild measles virus. Our analyses indicate influence of measles wild virus circulating in the population on immunological response to this virus in sera of patients with SSPE.