Wiadomosci lekarskie (Warsaw, Poland : 1960) · 2025
Effect of topically applied simvastatin plus Luteolin on enhancing the development of hair in male mice.
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Al-Mudhafar Ahmed Mh, Gany Sarmad Nory, Qassam Heider, Kadhum Marwa Ali, Hadi Najah Rayish
Аннотация
OBJECTIVE: Aim: The aim of this study to examine the effect of simvastatin and Luteolin in regrowing hair and stop hair loss in male mice.
PATIENTS AND METHODS: Materials and Methods: 25 adult male mice, weighing 25-35 g and aging 6-7 weeks, were employed. Male mice had their coat hairs on their dorsal skin, which was then carefully trimmed by an electrical machine and colored with a dye. Mice were divided into five equal groups (5 mice in each group) as follows: sham group (ethanol-treated group); Minoxidil-treated group; simvastatin-treated group; Luteolin-treated group; simvastatin and Luteolin coadministration group. The drugs were applied on the skin once daily for three weeks.
RESULTS: Results: We demonstrated that the tissue levels of total antioxidant capacity (TAC), vascular endothelia growth factor (VEGF) and keratinocyte growth factor (KGF) in the Minoxidil-treated group, simvastatin-treated group, Luteolin-treated group, and simvastatin and Luteolin coadministration group were considerably greater than those of the sham (ethanol) groups. Furthermore, these groups revealed significant increases in hair growth, hair count, and hair follicle diameters.
CONCLUSION: Conclusions: these results have identified that simvastatin and Luteolin significantly reduced hair loss due to their anti-inflammatory and antioxidant capabilities.
PATIENTS AND METHODS: Materials and Methods: 25 adult male mice, weighing 25-35 g and aging 6-7 weeks, were employed. Male mice had their coat hairs on their dorsal skin, which was then carefully trimmed by an electrical machine and colored with a dye. Mice were divided into five equal groups (5 mice in each group) as follows: sham group (ethanol-treated group); Minoxidil-treated group; simvastatin-treated group; Luteolin-treated group; simvastatin and Luteolin coadministration group. The drugs were applied on the skin once daily for three weeks.
RESULTS: Results: We demonstrated that the tissue levels of total antioxidant capacity (TAC), vascular endothelia growth factor (VEGF) and keratinocyte growth factor (KGF) in the Minoxidil-treated group, simvastatin-treated group, Luteolin-treated group, and simvastatin and Luteolin coadministration group were considerably greater than those of the sham (ethanol) groups. Furthermore, these groups revealed significant increases in hair growth, hair count, and hair follicle diameters.
CONCLUSION: Conclusions: these results have identified that simvastatin and Luteolin significantly reduced hair loss due to their anti-inflammatory and antioxidant capabilities.