Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood.
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Tao Min-Yi, Liu Xin, Chen Zi-Lin, Yang Meng-Nan, Xu Ya-Jie, He Hua, Fang Fang, Chen Qian, Mao Xuan-Xia, Zhang Jun, Ouyang Fengxiu, Shen Xiu-Hua, Li Fei, Luo Zhong-Cheng, Shanghai Birth Cohort, Shen Xiaoming, Huang Hong, Sun Kun, Zhang Jun, Wang Weiye, Xu Weiping, Ouyang Fengxiu, Li Fei, Huang Yin, Zhang Jinsong, Yan Chonghuai, Shen Lisong, Bao Yixiao, Tian Ying, Chen Weiwei, Zhang Huijuan, Tong Chuanliang, Xu Jian, Zhang Lin, Zhang Yiwen, Jiang Fang, Yu Xiaodan, Yu Guangjun, Chen Jinjin, Zhang Yu, Li Xiaotian, Cheng Haidong, Zhang Qinying, Duan Tao, Hua Jing, Peng Hua
Аннотация
METHODS: In the Shanghai Birth Cohort, we followed up 259 LGA (birth weight >90th percentile) and 1673 appropriate-for-gestational age (AGA, 10th-90th percentiles) children on body composition (by InBody 770) at age 4 years. Adiposity outcomes include body fat mass (BFM), percent body fat (PBF), body mass index (BMI), overweight/obesity, and high adiposity (PBF >85th percentile).
RESULTS: Three weight growth trajectories (low, mid, and high) during infancy (0-2 years) were identified in AGA and LGA subjects separately. BFM, PBF and BMI were progressively higher from low- to mid-to high-growth trajectories in both AGA and LGA children. Compared to the mid-growth trajectory, the high-growth trajectory was associated with greater increases in BFM and the odds of overweight/obesity or high adiposity in LGA than in AGA children (tests for interactions, all P < 0.05).
CONCLUSIONS: Weight trajectories during infancy affect adiposity in early childhood regardless of LGA or not. The study is the first to demonstrate that high-growth weight trajectory during infancy has a greater impact on adiposity in early childhood in LGA than in AGA subjects.
IMPACT: Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood, but little is known about how weight trajectories during infancy affect adiposity during early childhood in LGA subjects. The study is the first to demonstrate a greater impact of high-growth weight trajectory during infancy (0-2 years) on adiposity in early childhood (at age 4 years) in subjects with fetal overgrowth (LGA) than in those with normal birth size (appropriate-for-gestational age). Weight trajectory monitoring may be a valuable tool in identifying high-risk LGA children for close follow-ups and interventions to decrease the risk of obesity.