BMC endocrine disorders · 2021
Diagnosis and treatment of primary central nervous system lymphoma with the primary lesion in the hypothalamus: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Takao Ken, Tani Ayaka, Suwa Tetsuya, Kuwabara-Ohmura Yayoi, Nonomura Kenta, Liu Yanyan, Kato Takehiro, Mizuno Masami, Hirota Takuo, Enya Mayumi, Iizuka Katsumi, Horikawa Yukio, Saigo Chiemi, Kito Yusuke, Miyazaki Tatsuhiko, Ohe Naoyuki, Iwama Toru, Yabe Daisuke
Аннотация
BACKGROUND: Primary central nervous system lymphoma is a rare extra-nodal lymphoma of the central nervous system. Primary central nervous system lymphoma lesions usually appear in the vicinity of the ventricle, and there are few reports of primary central nervous system lymphoma with hypothalamic-pituitary lesions.
CASE PRESENTATION: We treated a 56-year-old male with primary central nervous system lymphoma with the primary lesion in the hypothalamus, which was found by magnetic resonance imaging after sudden onset of endocrinological abnormalities. Initially, he was hospitalized to our department for hyponatremia. Endocrinological examination in conjunction with head magnetic resonance imaging and endoscopic biopsy revealed hypothalamic hypopituitarism and tertiary hypoadrenocorticism caused by a rapidly growing, diffuse large B-cell lymphoma in the hypothalamus. Remission of the tumor was achieved by high-dose methotrexate with whole brain radiotherapy, and some of the hormone responses were normalized.
CONCLUSIONS: While primary central nervous system lymphoma is rare, it is important to note that hypopituitarism can result and that the endocrinological abnormalities can be partially restored by its remission.
CASE PRESENTATION: We treated a 56-year-old male with primary central nervous system lymphoma with the primary lesion in the hypothalamus, which was found by magnetic resonance imaging after sudden onset of endocrinological abnormalities. Initially, he was hospitalized to our department for hyponatremia. Endocrinological examination in conjunction with head magnetic resonance imaging and endoscopic biopsy revealed hypothalamic hypopituitarism and tertiary hypoadrenocorticism caused by a rapidly growing, diffuse large B-cell lymphoma in the hypothalamus. Remission of the tumor was achieved by high-dose methotrexate with whole brain radiotherapy, and some of the hormone responses were normalized.
CONCLUSIONS: While primary central nervous system lymphoma is rare, it is important to note that hypopituitarism can result and that the endocrinological abnormalities can be partially restored by its remission.
Предметные рубрики MeSH
Adrenal Cortex HormonesAntimetabolites, AntineoplasticCentral Nervous System NeoplasmsChemoradiotherapyCombined Modality TherapyEndocrine System DiseasesHormone Replacement TherapyHumansHypopituitarismHypothalamic NeoplasmsLymphoma, Large B-Cell, DiffuseMagnetic Resonance ImagingMaleMethotrexateMiddle AgedTreatment Outcome