Journal of autism and developmental disorders · 2006
Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion).
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Antshel Kevin M, Aneja Alka, Strunge Leslie, Peebles Jena, Fremont Wanda P, Stallone Kimberly, Abdulsabur Nuria, Higgins Anne Marie, Shprintzen Robert J, Kates Wendy R
Аннотация
The extent to which the phenotype of children comorbid for velocardiofacial syndrome (VCFS) and autism spectrum disorders (ASD) differs from that of VCFS-only has not been studied. The sample consisted of 41 children (20 females) with VCFS, ranging in age from 6.5 years to 15.8 years. Eight children with VCFS met formal DSM-IV diagnostic criteria for autism based upon the ADI-R. These eight plus an additional nine participants met diagnostic criteria for an autistic spectrum disorder (VCFS + ASD). Ninety-four percent of the children with VCFS + ASD had a co-occurring psychiatric disorder while 60% of children with VCFS had a psychiatric disorder. Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups.