Journal of pediatric and adolescent gynecology · 2013
Retrospective review of norethindrone use in adolescents.
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Santos M, Hendry Deborah, Sangi-Haghpeykar Haleh, Dietrich Jennifer E
Аннотация
STUDY OBJECTIVE: Our objectives were to review norethindrone use in an adolescent population in a tertiary care center and to assess the effectiveness of the norethindrone taper in the management of acute heavy menstrual bleeding in adolescents.
DESIGN: Retrospective cohort study.
SETTING: Tertiary care center.
PARTICIPANTS: 176 adolescent females prescribed norethindrone 0.35 mg between July 2007 and September 2010.
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Discontinuation and irregular bleeding rates.
RESULTS: Mean age was 14.8 ± 2.3 years. Most common indication for use was heavy menstrual bleeding (32.9%). Most common reasons for use of a progestin only pill were neurologic (27.8%) and cardiovascular diseases (17.6%). Discontinuation rate was 48.5%, most commonly for irregular bleeding (54.5%). Irregular bleeding and systemic side effects were associated with discontinuation (P = .006 and .003 respectively). No serious adverse events were reported. Twenty patients required norethindrone taper for heavy bleeding; of this group 78.9% experienced complete cessation of bleeding within 7 days.
CONCLUSIONS: Our findings support use of norethindrone as an effective alternative among adolescents with contraindications to administration of estrogen and for whom control of acute heavy menstrual bleeding is desired.
DESIGN: Retrospective cohort study.
SETTING: Tertiary care center.
PARTICIPANTS: 176 adolescent females prescribed norethindrone 0.35 mg between July 2007 and September 2010.
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Discontinuation and irregular bleeding rates.
RESULTS: Mean age was 14.8 ± 2.3 years. Most common indication for use was heavy menstrual bleeding (32.9%). Most common reasons for use of a progestin only pill were neurologic (27.8%) and cardiovascular diseases (17.6%). Discontinuation rate was 48.5%, most commonly for irregular bleeding (54.5%). Irregular bleeding and systemic side effects were associated with discontinuation (P = .006 and .003 respectively). No serious adverse events were reported. Twenty patients required norethindrone taper for heavy bleeding; of this group 78.9% experienced complete cessation of bleeding within 7 days.
CONCLUSIONS: Our findings support use of norethindrone as an effective alternative among adolescents with contraindications to administration of estrogen and for whom control of acute heavy menstrual bleeding is desired.