Future microbiology · 2017
In vitro susceptibility and resistance phenotypes in contemporary Enterobacter isolates in a university hospital in Crete, Greece.
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Maraki Sofia, Vardakas Konstantinos Z, Samonis George, Perdikis Dimitrios, Mavromanolaki Viktoria Eirini, Kofteridis Diamantis P, Falagas Matthew E
Аннотация
AIM: To study the evolution in the susceptibility of Enterobacter spp. in Crete, Greece from 2010 to 2015.
METHODS: Non-duplicate isolates were studied using automated systems. Phenotypic confirmatory tests were applied.
RESULTS: A total of 939 Enterobacter isolates were included. Colistin was the most active antibiotic (97.9%) followed by imipenem (96.1%), gentamicin (95.7%), tigecycline (91.8%), cefepime (89.4%), chloramphenicol (85.8%), fosfomycin (85.5%), trimethoprim/sulfamethoxazole (83.3%) and piperacillin/tazobactam (73.3%). Antibiotic resistance did not increase during the study period for most antibiotics. Lower susceptibility was observed among multidrug-resistant strains and carbapenem-nonsusceptible isolates. AmpC was the most common resistant mechanism (21%); carbapenemases (3.7%) and aminoglycoside-modifying enzymes (6.5%) were also detected.
CONCLUSION: A significant proportion of Enterobacter spp. was resistant to several antibiotics, most notably β-lactams.
METHODS: Non-duplicate isolates were studied using automated systems. Phenotypic confirmatory tests were applied.
RESULTS: A total of 939 Enterobacter isolates were included. Colistin was the most active antibiotic (97.9%) followed by imipenem (96.1%), gentamicin (95.7%), tigecycline (91.8%), cefepime (89.4%), chloramphenicol (85.8%), fosfomycin (85.5%), trimethoprim/sulfamethoxazole (83.3%) and piperacillin/tazobactam (73.3%). Antibiotic resistance did not increase during the study period for most antibiotics. Lower susceptibility was observed among multidrug-resistant strains and carbapenem-nonsusceptible isolates. AmpC was the most common resistant mechanism (21%); carbapenemases (3.7%) and aminoglycoside-modifying enzymes (6.5%) were also detected.
CONCLUSION: A significant proportion of Enterobacter spp. was resistant to several antibiotics, most notably β-lactams.
Предметные рубрики MeSH
AminoglycosidesAnti-Bacterial AgentsBacterial ProteinsCarbapenemsCefepimeCephalosporinsChildColistinDrug Resistance, Multiple, BacterialEnterobacterEnterobacteriaceae InfectionsGreeceHospitals, UniversityHumansMicrobial Sensitivity TestsMinocyclinePenicillanic AcidPhenotypePiperacillinPiperacillin, Tazobactam Drug CombinationTigecyclinebeta-Lactamasesbeta-Lactams