Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010
Survey for the presence of BK, JC, KI, WU and Merkel cell polyomaviruses in human brain tissues.
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Lam W Y, Leung B W, Chu Ida M T, Chan Alexander C L, Ng H K, Chan Paul K S
Аннотация
BACKGROUND: Recently three previously unknown polyomaviruses (KI, WU and Merkel cell polyomaviruses) have been identified from human specimens. The spectrum of clinical manifestations and their tissue tropism are currently unknown. Since a member of this virus family, JC virus, is well-known for its capacity to establish latency in human brain tissue where reactivation in immunocompromised individuals can result in fatal progressive multifocal leukoencephalopathy, we sought to examine for the presence of all the five known human polyomaviruses in a series of human brain tissues.
OBJECTIVES: To investigate the possibility of neuropersistence of the newly identified human polyomaviruses.
STUDY DESIGN: Autopsy brain tissues were collected from 10 different brain regions of 30 individuals who died from diseases unrelated to viral infections. Nested PCR was used to assess the presence or absence of viral DNA.
RESULTS: Ten samples collected from five individuals were found to harbour JCV DNA. In contrast, none of the 300 brain tissues examined showed positive results for BK, KI, WU or Merkel cell polyomavirus.
CONCLUSION: The newly identified KI, WU and Merkel cell polyomaviruses either do not, or have a much lower neuropersistent potential compared to JCV.
OBJECTIVES: To investigate the possibility of neuropersistence of the newly identified human polyomaviruses.
STUDY DESIGN: Autopsy brain tissues were collected from 10 different brain regions of 30 individuals who died from diseases unrelated to viral infections. Nested PCR was used to assess the presence or absence of viral DNA.
RESULTS: Ten samples collected from five individuals were found to harbour JCV DNA. In contrast, none of the 300 brain tissues examined showed positive results for BK, KI, WU or Merkel cell polyomavirus.
CONCLUSION: The newly identified KI, WU and Merkel cell polyomaviruses either do not, or have a much lower neuropersistent potential compared to JCV.