Annals of clinical biochemistry · 2014
Insulin resistance and brain-derived neurotrophic factor levels in chronic kidney disease.
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Marchelek-Myśliwiec Małgorzata, Cichocka Ewa, Dziedziejko Violetta, Dutkiewicz Gra Ż Yna, Stępniewska Joanna, Safranow Krzysztof, Budkowska Marta, Sałata Daria, Syrenicz Anhelli, Machaliński Bogusław, Ciechanowski Kazimierz
Аннотация
INTRODUCTION: Insulin resistance is a frequent abnormality in chronic kidney disease (CKD) appearing in early stages. Factors known to promote insulin resistance in CKD patients include disorders of ion and acid-base equilibrium and circulating uremia toxins. Recent research has focused on the central nervous system as the source of the brain-derived neurotrophic factor (BDNF). The aim of our work was to study plasma BDNF concentrations in stage 3 and 4 CKD patients in relationship with insulin resistance and distribution of adipose tissue.
METHOD: Plasma BDNF concentrations were measured in a study group of 31 patients, including a subgroup of 20 non-diabetic subjects. Additionally dual-energy X-ray absorptiometry (DXA) was performed. Homeostatic model assessment of insulin resistance (HOMA-IR) and homeostatic model assessment of B-cell function (HOMA-beta) indices were calculated.
RESULTS: Two separate analyses were performed. In the first analysis performed in all 31 CKD patients, there were no correlations between BDNF and: body mass index (BMI), android, gynoid fat distribution, HOMA-IR and HOMA-beta. In the second analysis performed in 20 CKD patients without diabetes, BDNF was negatively related to gynoid fat (Rs = -0.47, P = 0.034) and women revealed significantly lower levels of BDNF than men (P = 0.046). Normotensive patients disclosed significantly higher BDNF levels than hypertensive patients in the whole CKD group (P = 0.039) and in the non-diabetic subgroup (P = 0.028). No correlations between BDNF and eGFR were found.
CONCLUSIONS: Female sex and arterial hypertension are associated with lower BDNF plasma concentration in CKD patients.
METHOD: Plasma BDNF concentrations were measured in a study group of 31 patients, including a subgroup of 20 non-diabetic subjects. Additionally dual-energy X-ray absorptiometry (DXA) was performed. Homeostatic model assessment of insulin resistance (HOMA-IR) and homeostatic model assessment of B-cell function (HOMA-beta) indices were calculated.
RESULTS: Two separate analyses were performed. In the first analysis performed in all 31 CKD patients, there were no correlations between BDNF and: body mass index (BMI), android, gynoid fat distribution, HOMA-IR and HOMA-beta. In the second analysis performed in 20 CKD patients without diabetes, BDNF was negatively related to gynoid fat (Rs = -0.47, P = 0.034) and women revealed significantly lower levels of BDNF than men (P = 0.046). Normotensive patients disclosed significantly higher BDNF levels than hypertensive patients in the whole CKD group (P = 0.039) and in the non-diabetic subgroup (P = 0.028). No correlations between BDNF and eGFR were found.
CONCLUSIONS: Female sex and arterial hypertension are associated with lower BDNF plasma concentration in CKD patients.
Предметные рубрики MeSH
AdiposityBody Mass IndexBrain-Derived Neurotrophic FactorDiabetes Mellitus, Type 2Diabetic NephropathiesDown-RegulationFemaleHumansHypertensionInsulinInsulin ResistanceInsulin SecretionInsulin-Secreting CellsIntra-Abdominal FatMaleMiddle AgedPolandRenal Insufficiency, ChronicRisk FactorsSeverity of Illness IndexSex Characteristics