Bone marrow transplantation · 1999
Progressive multifocal leukoencephalopathy after autologous bone marrow transplantation and alpha-interferon immunotherapy.
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Re D, Bamborschke S, Feiden W, Schröder R, Lehrke R, Diehl V, Tesch H
Аннотация
A patient with a stage IV mantle cell lymphoma (according to the REAL classification) was treated with high-dose chemotherapy and autologous bone marrow transplantation. One year later while on alpha-interferon immunotherapy she suffered from progressive loss of short-term memory and reported difficulties in recognizing objects. Magnetic resonance imaging (MRI) showed a vast ring-enhancing lesion of the left postcentral parietal area. Serial stereotactic biopsies disclosed progressive multifocal leukoencephalopathy without JC-virus in the cerebrospinal fluid. Therapy with subcutaneous interleukin-2 (IL-2) every other day and intrathecal cytarabine once a week was started. After 4 weeks the patient refused further treatment. Nevertheless her condition improved over the next 8 months and MRI scans showed a marked improvement in the lesions.
Предметные рубрики MeSH
Antineoplastic Combined Chemotherapy ProtocolsBone Marrow TransplantationCarmustineCombined Modality TherapyCyclophosphamideCytarabineDexamethasoneEncephalitisEtoposideFemaleHumansImmunoglobulins, IntravenousImmunosuppression TherapyInjections, SpinalInterferon-alphaInterleukin-12Leukoencephalopathy, Progressive MultifocalLymphoma, Non-HodgkinMagnetic Resonance ImagingMelphalanMemory DisordersMiddle AgedPodophyllotoxinTransplantation ConditioningTransplantation, AutologousVincristine