The Journal of asthma : official journal of the Association for the Care of Asthma · 2008
Intake of paracetamol and risk of asthma in adults.
СтатьяTwin StudyНазвание и аннотация: Перевод в очереди
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Thomsen Simon Francis, Kyvik Kirsten Ohm, Skadhauge Lars, Steffensen Ida, Backer Vibeke
Аннотация
Intake of paracetamol has been associated with development of asthma. The aim of this study was to address a possible association between intake of paracetamol and risk of adult-onset asthma. Using a multidisciplinary postal questionnaire survey concerning health and lifestyle we prospectively studied 19,349 adult twins enrolled in the nationwide Danish Twin Registry. There was a higher prevalence of new-onset asthma in subjects who reported frequent intake of paracetamol at baseline compared with subjects without this determinant (12.0% vs. 4.3%), OR = 3.03 (1.51-6.11), p = 0.005. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema, and intake of medications other than paracetamol, OR = 2.16 (1.03-4.53), p = 0.041. Frequent intake of paracetamol is an independent risk factor for adult-onset asthma.