Current medicinal chemistry · 2024
Recent Advances on the Antimicrobial Activities of Schiff Bases and their Metal Complexes: An Updated Overview.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
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Jorge Juliana, Del Pino Santos Kristiane Fanti, Timóteo Fernanda, Vasconcelos Rafael Rodrigo Piva, Ayala Cáceres Osmar Ignacio, Granja Isis Juliane Arantes, de Souza David Monteiro, Frizon Tiago Elias Allievi, Di Vaccari Botteselle Giancarlo, Braga Antonio Luiz, Saba Sumbal, Rashid Haroon Ur, Rafique Jamal
Аннотация
Schiff bases represent a valuable class of organic compounds, synthesized via condensation of primary amines with ketones or aldehydes. They are renowned for possessing innumerable applications in agricultural chemistry, organic synthesis, chemical and biological sensing, coating, polymer and resin industries, catalysis, coordination chemistry, and drug designing. Schiff bases contain imine or azomethine (-C=N-) functional groups which are important pharmacophores for the design and synthesis of lead bioactive compounds. In medicinal chemistry, Schiff bases have attracted immense attention due to their diverse biological activities. This review aims to encompass the recent developments on the antimicrobial activities of Schiff bases. The article summarizes the antibacterial, antifungal, antiviral, antimalarial, and antileishmanial activities of Schiff bases reported since 2011.