Journal of perinatology : official journal of the California Perinatal Association · 2016
Maternal apolipoprotein E genotype as a potential risk factor for poor birth outcomes: The Bogalusa Heart Study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Jacobs M B, Harville E W, Kelly T N, Bazzano L A, Chen W
Аннотация
OBJECTIVE: The objective of this study was to assess the association between apolipoprotein E (apoE) genotype and preterm birth (PTB) and small for gestational age (SGA).
STUDY DESIGN: ApoE phenotyping was performed on 680 women linked to 1065 births. Allele frequencies were compared and PTB and SGA risk was estimated using log-binomial regression.
RESULTS: The ɛ2 allele was more common in SGA births (P<0.01). SGA risk was increased among ɛ2 carriers compared with genotype ɛ3/ɛ3, though associations were attenuated following adjustment for maternal age, education, race, smoking and prenatal visits. Stronger associations were observed for term SGA (first birth: adjusted relative risk (aRR)=1.78, 95% confidence interval (CI) 1.06 to 2.98; any birth: aRR=1.52, 95% CI 0.96 to 2.40) and among whites specifically (first: aRR=2.88, 95% CI 1.45 to 5.69; any: aRR=2.75, 95% CI 1.46 to 5.22).
CONCLUSIONS: Associations between maternal apoE genotype and SGA may represent decreased fetal growth in women with lower circulating cholesterol levels.
STUDY DESIGN: ApoE phenotyping was performed on 680 women linked to 1065 births. Allele frequencies were compared and PTB and SGA risk was estimated using log-binomial regression.
RESULTS: The ɛ2 allele was more common in SGA births (P<0.01). SGA risk was increased among ɛ2 carriers compared with genotype ɛ3/ɛ3, though associations were attenuated following adjustment for maternal age, education, race, smoking and prenatal visits. Stronger associations were observed for term SGA (first birth: adjusted relative risk (aRR)=1.78, 95% confidence interval (CI) 1.06 to 2.98; any birth: aRR=1.52, 95% CI 0.96 to 2.40) and among whites specifically (first: aRR=2.88, 95% CI 1.45 to 5.69; any: aRR=2.75, 95% CI 1.46 to 5.22).
CONCLUSIONS: Associations between maternal apoE genotype and SGA may represent decreased fetal growth in women with lower circulating cholesterol levels.