Urologiia (Moscow, Russia : 1999) · 2008
[Trospium chloride in combined treatment of females with genital prolapse and overactive urinary bladder].
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Shkol'nikov M e, Mazo E B, Krivoborodov G G, Dobrokhotova Iu E, Kaĭfadzhan M M, Fandeeva L V, Nurullin R F, Zhdanova M S
Аннотация
The trial of efficacy of trospium chloride (TC) in a dose of 45 mg/day in females with overactive bladder (OAB) symptoms preserved after genital prolapse (GP) surgical correction included 28 females (age 55-82, mean age 68.07 +/- 12 years). GP was corrected by means of vaginal hysterectomy and anterior colporraphy. Treatment results were assessed 3 months after surgery basing on urine diary. Overall TC efficacy reached 82%. Symptoms attenuated in patients with and without detrusor overactivity: voiding frequency reduced by 31 and 24%, imperative voidings reduced by 26 and 8%, mean urine volume rose by 28 and 19%, respectively. Side effects were mild. TC demonstrated good efficacy in OAB patients, it noticeably improved quality of life.