International journal of clinical pharmacy · 2011
Effects of an operational multidisciplinary team on hospital antibiotic use and cost in France: a cluster controlled trial.
Сравнительное исследованиеКонтролируемое клиническое исследованиеСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bevilacqua Sibylle, Demoré Béatrice, Erpelding Marie-Line, Boschetti Emmanuelle, May Thierry, May Isabelle, Rabaud Christian, Thilly Nathalie
Аннотация
OBJECTIVE: The study objective was to evaluate the effectiveness of an operational multidisciplinary antibiotic team, including an infectious disease physician and a clinical pharmacist, in reducing the hospital antimicrobial consumption and costs.
SETTING: The 1800-bed University Hospitals of Nancy (France).
METHOD: A cluster controlled 'before-after' study was performed. The intervention group comprised 11 medical and surgical wards in settings where the operational antibiotic team was implemented, and the control group comprised 6 wards without this operational team. The 'before' period (2005) preceded the implementation of the operational team in the intervention group and 'after' (July 2007 to June 2008) followed its full implementation.
MAIN OUTCOME MEASURE: We compared consumption of antibiotics overall and by therapeutic class (in defined daily doses per 1,000 patient days) and cost savings (in <euro>) between 'before' and 'after' in both groups (control and intervention), using a mixed effect linear model.
RESULTS: The overall consumption of antibiotics decreased after implementation of the operational team by 33.6% in the intervention group and by 3.3% in the control group (P = 0.003). Compared with the control group, the decrease in antibiotic use in the intervention group was significantly higher for various therapeutic classes (broad-spectrum penicillins, injectable fluoroquinolones, glycopeptides) and specific drugs (imipenem, ciprofloxacin, teicoplanin). For the same activity, the total cost savings were 14-fold higher in the intervention group.
CONCLUSION: Establishment of an operational multidisciplinary team may be an effective way to reduce hospital antibiotic use and cost, with a good acceptance rate among prescribers.
SETTING: The 1800-bed University Hospitals of Nancy (France).
METHOD: A cluster controlled 'before-after' study was performed. The intervention group comprised 11 medical and surgical wards in settings where the operational antibiotic team was implemented, and the control group comprised 6 wards without this operational team. The 'before' period (2005) preceded the implementation of the operational team in the intervention group and 'after' (July 2007 to June 2008) followed its full implementation.
MAIN OUTCOME MEASURE: We compared consumption of antibiotics overall and by therapeutic class (in defined daily doses per 1,000 patient days) and cost savings (in <euro>) between 'before' and 'after' in both groups (control and intervention), using a mixed effect linear model.
RESULTS: The overall consumption of antibiotics decreased after implementation of the operational team by 33.6% in the intervention group and by 3.3% in the control group (P = 0.003). Compared with the control group, the decrease in antibiotic use in the intervention group was significantly higher for various therapeutic classes (broad-spectrum penicillins, injectable fluoroquinolones, glycopeptides) and specific drugs (imipenem, ciprofloxacin, teicoplanin). For the same activity, the total cost savings were 14-fold higher in the intervention group.
CONCLUSION: Establishment of an operational multidisciplinary team may be an effective way to reduce hospital antibiotic use and cost, with a good acceptance rate among prescribers.