Childhood abuse, promoter methylation of leukocyte NR3C1 and the potential modifying effect of emotional support.

AIM: To investigate childhood abuse victimization in relation to adult DNA methylation levels in a novel region of NR3C1, with emotional support as a possible modifier.

MATERIALS &

METHODS

295 participants from the Black Women's Health Study. Multivariable linear regression models were used to compute differences in mean percent methylation levels.

RESULTS

Women reporting childhood abuse victimization exhibited higher mean NR3C1 methylation levels than nonabused women, with a clear dose-response relationship. Childhood emotional support appeared to attenuate associations only among women with the highest levels of physical and sexual abuse.

CONCLUSION

NR3C1 mean methylation was higher among women who reported childhood abuse. Further research is warranted to clarify whether or the extent to which childhood emotional support buffers the association.