Toxicon : official journal of the International Society on Toxinology · 2017
Renal effects of Bunodosoma caissarum crude extract: Prostaglandin and endothelin involvement.
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Martins René Duarte, Jorge Roberta Jeane Bezerra, Alves Renata de Sousa, Silva Neto Antônio Gomes da, Barbosa Paulo Sergio F, Costa Martins Alice Maria, Toyama Marcos H, Monteiro Helena Serra Azul
Аннотация
Sea anemones contain a variety of interesting biologically active compounds, including some potent toxins. PLA2 from Bunodosoma caissarum, a sea anemone endemic in the Brazilian southern coast, has shown renal alterations on isolated kidney. The aim of this study was to evaluate the renal and vascular effects of B. caissarum crude extract (BcE) on isolated perfused kidney and arteriolar mesenteric bed, as well the involvement of prostaglandins and endothelin. BcE did not show any effect on arteriolar mesenteric bed, but increased perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and decreased the percentage of sodium tubular transport on isolated perfused kidney. Indomethacin blocked the renal effects induced by BcE and tezosentan only partially blocked these effects. These results demonstrate the effects of BcE on kidney in situ, suggesting the involvement of prostaglandins and endothelin.