The American journal of tropical medicine and hygiene · 2019
Japanese Encephalitis- and Dengue-Associated Acute Encephalitis Syndrome Cases in Myanmar.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kyaw Aung Kyaw, Ngwe Tun Mya Myat, Nabeshima Takeshi, Buerano Corazon C, Ando Tsuyoshi, Inoue Shingo, Hayasaka Daisuke, Lim Chang-Kweng, Saijo Masayuki, Thu Hlaing Myat, Thant Kyaw Zin, Morita Kouichi
Аннотация
This study was conducted to find the burden of dengue virus (DENV) and Japanese encephalitis virus (JEV) among children under the age of 13, who presented with acute encephalitis syndrome at Mandalay Children Hospital in Myanmar in 2013. Molecular and serological investigations were performed on 123 cerebrospinal fluid (CSF) samples collected from these patients. By neutralization tests and/or virus isolation, four (3.3%) JEV- and one DENV-associated encephalitis cases (0.8%) were confirmed. Antibody titer against JEV Genotype 3 was the highest among the laboratory-confirmed JEV cases. One strain of DENV-1 with Genotype 1 was isolated from the CSF sample of the dengue encephalitis patient; this was similar to the virus circulating in the study area and neighboring countries. This study shows that flaviviruses are important pathogens causing encephalitis in Myanmar. Active disease surveillance, vector control, and vaccination programs should be enforced to reduce the morbidity and mortality caused by flavivirus encephalitis.