Fertility and sterility · 2010
Dendritic cells are equally distributed in intrauterine and tubal ectopic pregnancies.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kemp Birgit, Schmitz Svenja, Krusche Claudia A, Rath Werner, von Rango Ulrike
Аннотация
OBJECTIVE: To examine different stages of dendritic cells (DCs) in intrauterine (IUPs) and viable tubal (VTPs) pregnancies to further elucidate mechanisms of fetomaternal tolerance and extravillous trophoblast invasion.
DESIGN: Experimental study on patient-controlled material.
SETTING: University hospital.
PATIENT(S): Seven women with normal IUPs and ten with VTPs in the first trimester.
INTERVENTION(S): Suction curettage in IUP, laparoscopy in VTP.
MAIN OUTCOME MEASURE(S): Immunohistochemistry for cytokeratin-7 (trophoblast), CD83 (mature DCs), DEC205 (activated but not fully mature DCs), DC-SIGN (immature macrophage-like DCs), and CD14 (macrophages) alone and in double staining.
RESULT(S): The numbers of CD83+ and DEC205+ cells were similarly low in IUP and VTP (0.83 and 0.44 cells/mm2; 2.28 and 2.96 cells/mm2). The number of DC-SIGN+ cells was higher, though without significant differences among the entities examined (57.5 and 47.4 cells/mm2). About two-thirds of DC-SIGN+ cells were also CD14+ in IUP and VTP.
CONCLUSION(S): The almost equal distribution of CD83+, DEC205+, and DC-SIGN+ cells in IUP and VTP suggests analogue control mechanisms in intrauterine and extrauterine DC differentiation and a comparable role of these DCs for the development of fetomaternal tolerance.
DESIGN: Experimental study on patient-controlled material.
SETTING: University hospital.
PATIENT(S): Seven women with normal IUPs and ten with VTPs in the first trimester.
INTERVENTION(S): Suction curettage in IUP, laparoscopy in VTP.
MAIN OUTCOME MEASURE(S): Immunohistochemistry for cytokeratin-7 (trophoblast), CD83 (mature DCs), DEC205 (activated but not fully mature DCs), DC-SIGN (immature macrophage-like DCs), and CD14 (macrophages) alone and in double staining.
RESULT(S): The numbers of CD83+ and DEC205+ cells were similarly low in IUP and VTP (0.83 and 0.44 cells/mm2; 2.28 and 2.96 cells/mm2). The number of DC-SIGN+ cells was higher, though without significant differences among the entities examined (57.5 and 47.4 cells/mm2). About two-thirds of DC-SIGN+ cells were also CD14+ in IUP and VTP.
CONCLUSION(S): The almost equal distribution of CD83+, DEC205+, and DC-SIGN+ cells in IUP and VTP suggests analogue control mechanisms in intrauterine and extrauterine DC differentiation and a comparable role of these DCs for the development of fetomaternal tolerance.
Предметные рубрики MeSH
Antigens, CDCell Adhesion MoleculesDendritic CellsFemaleHumansImmune ToleranceImmunoglobulinsImmunohistochemistryKeratin-7Lectins, C-TypeLipopolysaccharide ReceptorsMacrophagesMembrane GlycoproteinsMinor Histocompatibility AntigensPregnancyPregnancy Trimester, FirstPregnancy, TubalReceptors, Cell SurfaceTrophoblastsCD83 AntigenDC-Specific ICAM-3 Grabbing Nonintegrin