CNS & neurological disorders drug targets · 2023
Benzodiazepines and Sleep Architecture: A Systematic Review.
Систематический обзорСтатьяНазвание и аннотация: Перевод в очереди
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de Mendonça Felipe Maraucci Ribeiro, de Mendonça Giulia Paulo Rossi Ribeiro, Souza Laura Costa, Galvão Lucas Pequeno, Paiva Henrique Soares, de Azevedo Marques Périco Cintia, Torales Julio, Ventriglio Antonio, Castaldelli-Maia Joao Maurício, Sousa Martins Silva Anderson
Аннотация
BACKGROUND: Insomnia, defined as a difficulty in initiating or maintaining sleep, is a relevant medical issue. Benzodiazepines (BZDs) are commonly prescribed to treat insomnia. Two phases characterize human sleep structure: sleep with Non-Rapid Eye Movement (NREM) and sleep with Rapid Eye Movement (REM). Physiological sleep includes NREM and REM phases in a continuous cycle known as "Sleep Architecture."
OBJECTIVE: This systematic review summarizes the studies that have investigated effects of BZDs on Sleep Architecture.
METHODS: The articles selection included human clinical trials (in English, Portuguese, or Spanish) only, specifically focused on BZDs effects on sleep architecture. PubMed, BVS, and Google Scholar databases were searched.
RESULTS: Findings on BZDs effects on sleep architecture confirm an increase in stage 2 of NREM sleep and a decrease in time of stages 3 and 4 of NREM sleep with a reduction in time of REM sleep during the nocturnal sleep.
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.
OBJECTIVE: This systematic review summarizes the studies that have investigated effects of BZDs on Sleep Architecture.
METHODS: The articles selection included human clinical trials (in English, Portuguese, or Spanish) only, specifically focused on BZDs effects on sleep architecture. PubMed, BVS, and Google Scholar databases were searched.
RESULTS: Findings on BZDs effects on sleep architecture confirm an increase in stage 2 of NREM sleep and a decrease in time of stages 3 and 4 of NREM sleep with a reduction in time of REM sleep during the nocturnal sleep.
CONCLUSION: Variations in NREM and REM sleep may lead to deficits in concentration and working memory and weight gain. The increase in stage 2 of NREM sleep may lead to a subjective improvement of sleep quality with no awakenings. BZDz should be prescribed with zeal and professional judgment. These patients should be closely monitored for possible long-term side effects.