The anti ulcerogenic effect of sildenafil and moringa on ulcers in rats.

BACKGROUND

Moringa and Sildenafil oleifera (MO) have been shown to mitigate the ulcerogenic effects of medications that induce ulcers in rats.

OBJECTIVE

the goal of This research is to assess the combined protective effects of Sildenafil citrate and the Indian herb Moringa oleifera against indomethacin-induced gastric ulcers in rats.

MATERIALS AND

METHODS

Gastric ulcers were induced in rats by oral administration of indomethacin. Forty-eight rats were randomly distributed into six groups: Group 1 (control); Group 2 (indomethacin 60 mg/kg); Group 3 (sildenafil 50 mg/kg prior to indomethacin); Group 4 (Moringa leaf powder 200 mg/kg prior to indomethacin); Group 5 (both sildenafil and Moringa prior to indomethacin); and Group 6 (omeprazole prior to indomethacin).

RESULTS

Indomethacin significantly increased gastric mucosal ulceration in comparison to the control group. Rats in the indomethacin group exhibited elevated levels of Caspase 3, tumor necrosis factor-α (TNF-α), and malondialdehyde (MDA), while nitric oxide (NO) levels were reduced. Pretreatment with omeprazole resulted in a reduction of MDA, TNF-α, and Caspase 3 levels, but had no effect on NO levels. Pretreatment with sildenafil and/or Moringa significantly impacting the ulcer scores and make it less, increased NO levels, and decreased tissue MDA and TNF-α levels.

CONCLUSION

The study concludes that Sildenafil and Moringa oleifera exhibit gastroprotective effects in experimentally induced gastric ulcer models in rats.