Emerging infectious diseases · 2015
Infectious causes of encephalitis and meningoencephalitis in Thailand, 2003-2005.
Историческая статьяСтатьяМногоцентровое исследованиеПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Olsen Sonja J, Campbell Angela P, Supawat Krongkaew, Liamsuwan Sahas, Chotpitayasunondh Tawee, Laptikulthum Somsak, Viriyavejakul Akravudh, Tantirittisak Tasanee, Tunlayadechanont Supoch, Visudtibhan Anannit, Vasiknanonte Punnee, Janjindamai Supachai, Boonluksiri Pairoj, Rajborirug Kiatsak, Watanaveeradej Veerachai, Khetsuriani Nino, Dowell Scott F, Thailand Encephalitis Surveillance Team
Аннотация
Acute encephalitis is a severe neurologic syndrome. Determining etiology from among ≈100 possible agents is difficult. To identify infectious etiologies of encephalitis in Thailand, we conducted surveillance in 7 hospitals during July 2003-August 2005 and selected patients with acute onset of brain dysfunction with fever or hypothermia and with abnormalities seen on neuroimages or electroencephalograms or with cerebrospinal fluid pleocytosis. Blood and cerebrospinal fluid were tested for >30 pathogens. Among 149 case-patients, median age was 12 (range 0-83) years, 84 (56%) were male, and 15 (10%) died. Etiology was confirmed or probable for 54 (36%) and possible or unknown for 95 (64%). Among confirmed or probable etiologies, the leading pathogens were Japanese encephalitis virus, enteroviruses, and Orientia tsutsugamushi. No samples were positive for chikungunya, Nipah, or West Nile viruses; Bartonella henselae; or malaria parasites. Although a broad range of infectious agents was identified, the etiology of most cases remains unknown.