Himalaflavones F and G, two new flavonoids from the roots of Oxybaphus himalaicus Edgew with anti-inflammatory activity.

Himalaflavones F (1) and G (2), two new flavonoids, along with eight known ones (3-10)were isolated from the roots of Oxybaphus himalaicus Edgew. The chemical structures of these compounds were elucidated by 1D/2D NMR, UV and HR-ESI-ME data. Meanwhile, the anti-inflammatory activities of all isolates were test by using Griess method. Among them 10 μM of compounds 1, 2, 8 and 10 could decrease the NO release against LPS-induced RAW264.7 macrophages. The results suggested that these compounds have the potential to be developed as anti-inflammatory drugs.