Clinical epigenetics · 2023
Evaluation of pediatric epigenetic clocks across multiple tissues.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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История · было → стало
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Fang Fang, Zhou Linran, Perng Wei, Marsit Carmen J, Knight Anna K, Cardenas Andres, Aung Max T, Hivert Marie-France, Aris Izzuddin M, Goodrich Jaclyn M, Smith Alicia K, Gaylord Abigail, Fry Rebecca C, Oken Emily, O'Connor George, Ruden Douglas M, Trasande Leonardo, Herbstman Julie B, Camargo Carlos A, Bush Nicole R, Dunlop Anne L, Dabelea Dana M, Karagas Margaret R, Breton Carrie V, Ober Carole, Everson Todd M, Page Grier P, Ladd-Acosta Christine, program collaborators for Environmental influences on Child Health Outcomes
Аннотация
BACKGROUND: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
RESULTS: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.
CONCLUSIONS: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
RESULTS: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.
CONCLUSIONS: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.