American journal of physiology. Lung cellular and molecular physiology · 2006
Vascular endothelial growth factor in the lung.
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Voelkel Norbert F, Vandivier R William, Tuder Rubin M
Аннотация
Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; many different lung cells produce VEGF and also respond to VEGF. VEGF is critical for the development of the lung and serves as a maintenance factor during adult life. In addition to the physiological functions of this protein, there is increasing evidence that VEGF also plays a role in several acute and chronic lung diseases, such as acute lung injury, severe pulmonary hypertension, and emphysema. Here we provide a comprehensive overview of the rapidly expanding literature.
Предметные рубрики MeSH
AnimalsAsthmaEmphysemaEndothelial CellsFetal DistressHumansHyperoxiaHypertension, PulmonaryInfant, NewbornLungLung DiseasesLung NeoplasmsMembrane ProteinsProteinsReceptors, Vascular Endothelial Growth FactorRespiratory Distress SyndromeRespiratory Distress Syndrome, NewbornSignal TransductionVascular Endothelial Growth Factor A