Health risk assessment of trihalomethanes mixtures from daily water-related activities via multi-pathway exposure based on PBPK model.

In this study, the concentrations of trihalomethanes (THMs) in tap water and direct drinking water were analyzed, and based on the human behavior patterns and building parameters, the concentrations of THMs in indoor air were simulated with the water-air concentration conversion model. In addition, concentrations of THMs in human tissues were predicted based on physiologically based pharmacokinetic (PBPK) model, and the health risk of THMs for participants were estimated. Furthermore, the carcinogenic risk of mixtures according to the method proposed by USEPA and PBPK model based method were calculated and compared. The concentrations of chloroform, bromodichloromethane, dibromochloromethane and bromoform in tap water were 11.28-16.21, 4.83-6.28, 0.81-1.32 and 0.08-0.21 μg/L, and those in direct drinking water were 3.29-6.88, 0.35-0.47, 0.03-0.08 and 0.04-0.08 μg/L, respectively. The results of water-air concentration conversion model demonstrated that pollutants in air had a strong correlation with water-related activities. Multi-pathway PBPK model showed that THMs concentrations in liver, kidney and richly perfused tissue were higher than those in other tissues. The results of risk assessment showed that the mean risk levels of mixtures were 1.69 × 10-4 and 1.72 × 10-4 calculated by the USEPA recommended method and PBPK based method, which seriously exceeded the acceptable level. TCM and BDCM were the major risk factors, and inhalation was the main exposure route of THMs.