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Войти в исследования Predominance of arboviruses in acute encephalitis and Guillain-Barré syndrome: Findings from a prospective cohort in Northeast Brazil.
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do Rosário Mateus Santana, Sampaio Maria Paula de Souza, Martins Lorena Cunha, Trindade Luiza Vieira Luedy, Carreiro Gabriela Farias, Franco E Castro Breno Pinheiro de Almeida, Costa Bernardo Gratival Gouvea, Vasconcelos Gessica Almeida, Dias Jesângeli de Souza, Duarte Alan Oliveira, Habib Fernanda Lopes, Souza Cassia Flavia Moreira, Conceição Pedro Sampaio Almeida Ramos, Souza Mariellen Santos de Jesus, de Jesus Pedro Antonio Pereira, Farias Daniel Santana, Souza Murilo Santos, Galvão Adilson Junior Pinto, Costa Felipe Oliveira, Farias Tarsis Leonardo Almeida, Filho Jamary Oliveira, Fukuda Thiago Gonçalves, Silvany Celia, Chagas Janeusa Rita Leite Primo, Teles Jose Mário Meira, Campos Gubio Soares, Sardi Silvia Inês, Santos Ively Paixão, Khouri Ricardo, Bessa Marcia Carvalho, de Lima Maricelia Maia, Gräf Tiago, de Siqueira Isadora Cristina
Аннотация
METHODS: We conducted a prospective, hospital-based cohort (March 2020 to August 2025) including patients with suspected viral neurological syndromes. Systematic testing combined qRT-PCR and serology for arboviruses (CHIKV, DENV, ZIKV, OROV) with multiplex PCR for classical neurotropic viruses. Clinical, imaging, EEG, and ENMG data were collected using standardized electronic forms. Temporal and seasonal trends were analyzed using quasi-Poisson and cyclic generalized additive models.
RESULTS: Among 132 patients, encephalitis (58%, 76/132) and Guillain-Barré syndrome (23%, 30/132) predominated. A viral etiology was identified in 42% (56/132), mostly arboviral. CHIKV (41%, 23/56) was the most frequent pathogen, followed by DENV (26%, 15/56) and OROV (11%, 6/56%), while HSV-1 was rare. GBS showed a significant upward trend and seasonal pattern, contrasting with stable encephalitis incidence. CSF, imaging, and electrophysiological findings were heterogeneous, reflecting complex diagnostic patterns.
CONCLUSIONS: Arboviruses-particularly CHIKV, DENV, and emerging OROV-are leading causes of acute neurological syndromes in Brazil. The integration of multiplex viral panels and arboviral assays is essential to enhance diagnosis. Strengthened surveillance and molecular diagnostics are critical in regions with arboviral circulation.