Медицинская библиотека · Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2011

Biomarkers of age effect on renal function in Down syndrome.

Guzmán Rodrigo, Campos Carlos, López-Fernández Encarnación, Casado Angela

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

OBJECTIVE

To assess differences in kidney function between Down syndrome (DS) individuals and a control group related to aging.

METHODS

Creatinine (Cr) and specific gravity (SG) were assessed by spectrophotometric and refractometric assays in urine samples of 103 individuals with DS and 82 age-matched controls.

RESULTS

Significantly lower levels of Cr and SG were found in DS after puberty. Significant correlations were found between SG and age as well as between Cr and SG in DS and controls (p ≤ 0.05).

CONCLUSIONS

Premature aging in kidneys of DS patients could lead to an impaired renal function.

Для цитирования: Guzmán Rodrigo, Campos Carlos, López-Fernández Encarnación, Casado Angela. Biomarkers of age effect on renal function in Down syndrome.. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2011. DOI: 10.3109/1354750x.2011.626527.

Предметные рубрики MeSH

Adolescent Adult Biomarkers Case-Control Studies Child Child, Preschool Creatinine Down Syndrome Female Humans Infant Kidney Male Middle Aged Young Adult

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