Advances in skin & wound care · 2017
Effectiveness and Safety of a Thermosensitive Hydrogel Cultured Epidermal Allograft for Burns.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yoon Jaechul, Yang Hyeong-Tae, Yim Haejun, Cho Yong-Suk, Kym Dohern, Hur Jun, Chun Wook, Lee Jong-Wook, Yoon Chunjae
Аннотация
OBJECTIVE: To retest the safety and effectiveness of a thermosensitive hydrogel-type cultured epithelial allograft (KeraHeal-Allo; MCTT, Seoul, South Korea) and identify the subjective experience of patients and doctors with this product.
DESIGN AND SETTING: Prospective interventional phase 3 study in 3 burn centers near Seoul, South Korea.
PATIENTS: Thirty-three patients with deep second-degree burns larger than 200 cm (for intervention and control sites of 100 cm each) were enrolled.
INTERVENTION: A cultured epithelial allograft containing 2 × 10/1.5 mL keratinocytes was applied to each patient's intervention site. Three principal investigators (1 in each institution) evaluated the effectiveness of the allograft at their institution and the others'. Researchers administered a subjective satisfaction survey during each patient's last visit.
MAIN OUTCOME MEASURE: The primary end point of the study was the re-epithelialization period.
MAIN RESULTS: The re-epithelialization period for the intervention was 2.8 ± 2.2 days faster than that of control sites at other institutions (P < .001) and 2.5 ± 3.4 days faster than that of control sites in the same institution (P < .001). There were no reported adverse events. Satisfaction scores provided by patients and doctors showed significantly high scores on all items.
CONCLUSUIONS: This type of cultured epithelial allograft is safe and well received by patients and providers and promotes re-epithelialization.
DESIGN AND SETTING: Prospective interventional phase 3 study in 3 burn centers near Seoul, South Korea.
PATIENTS: Thirty-three patients with deep second-degree burns larger than 200 cm (for intervention and control sites of 100 cm each) were enrolled.
INTERVENTION: A cultured epithelial allograft containing 2 × 10/1.5 mL keratinocytes was applied to each patient's intervention site. Three principal investigators (1 in each institution) evaluated the effectiveness of the allograft at their institution and the others'. Researchers administered a subjective satisfaction survey during each patient's last visit.
MAIN OUTCOME MEASURE: The primary end point of the study was the re-epithelialization period.
MAIN RESULTS: The re-epithelialization period for the intervention was 2.8 ± 2.2 days faster than that of control sites at other institutions (P < .001) and 2.5 ± 3.4 days faster than that of control sites in the same institution (P < .001). There were no reported adverse events. Satisfaction scores provided by patients and doctors showed significantly high scores on all items.
CONCLUSUIONS: This type of cultured epithelial allograft is safe and well received by patients and providers and promotes re-epithelialization.