Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2020
Biomarkers of neurotoxicity, oxidative stress, hepatotoxicity and lipid peroxidation in Clarias gariepinus exposed to melamine and polyvinyl chloride.
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Iheanacho Stanley Chidi, Igberi Christiana, Amadi-Eke Akunna, Chinonyerem Delight, Iheanacho Angus, Avwemoya Fred
Аннотация
PURPOSE: Plastic particulates and chemicals are emerging environmental pollutants with significant impact on aquatic ecosystems. In this study, the effects of oral uptake of melamine, melamine formaldehyde, and polyvinyl chloride on serum biochemical profiles, antioxidant enzymes activities, lipid peroxidation levels and brain acetyl cholinesterase activities in Clarias gariepinus juveniles were investigated.
METHODS: Fish specimens were fed diets spiked with melamine, melamine formaldehyde and poly vinyl chloride at 0.3% (3.0 g Kg-1) dietary inclusion for 45 days. Toxicity effect of these plastic chemicals was estimated by assaying relevant biomarkers.
RESULTS: After 45 days exposure, Serum glucose was significantly elevated, whereas plasma protein levels were substantially reduced in the exposed fish groups. Serum transaminases were significantly elevated in the exposed groups. Brain acetylcholinesterase and antioxidant enzyme activities declined significantly, while malondialdehyde levels were elevated in the exposed groups.
CONCLUSION: C. gariepinus is an important bioindicator to monitor the ecotoxicological impact of plastic chemicals such as melamine, and polyvinyl chloride.
METHODS: Fish specimens were fed diets spiked with melamine, melamine formaldehyde and poly vinyl chloride at 0.3% (3.0 g Kg-1) dietary inclusion for 45 days. Toxicity effect of these plastic chemicals was estimated by assaying relevant biomarkers.
RESULTS: After 45 days exposure, Serum glucose was significantly elevated, whereas plasma protein levels were substantially reduced in the exposed fish groups. Serum transaminases were significantly elevated in the exposed groups. Brain acetylcholinesterase and antioxidant enzyme activities declined significantly, while malondialdehyde levels were elevated in the exposed groups.
CONCLUSION: C. gariepinus is an important bioindicator to monitor the ecotoxicological impact of plastic chemicals such as melamine, and polyvinyl chloride.