International journal of radiation oncology, biology, physics · 2018
Breast Cancer, Secondary Breast Cancers in Childhood Cancer Male Survivors-Characteristics and Risks.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Demoor-Goldschmidt Charlotte, Allodji Rodrigue S, Jackson Angela, Vu-Bezin Giao, Souchard Vincent, Fresneau Brice, le Fayech Chiraz, Haddy Nadia, Rubino Carole, Pacquement Helène, Veres Cristina, Llanas Damien, Diallo Ibrahima, de Vathaire Florent
Аннотация
PURPOSE: Male breast cancer (MBC) is uncommon, accounting for less than 1% of all breast cancers. Secondary breast cancers among childhood cancer survivors have been well described in the literature, but less is known about MBC.
METHODS AND MATERIALS: We carried out an analysis in a cohort of 7019 five-year survivors of a solid childhood (aged ≤20 years) cancer treated in France before 2001 and followed for an average of 20 years and compared breast cancers occurring in both men and women.
RESULTS: Among the 7019 survivors, 4 out of 3893 male survivors developed breast cancer, compared with 99 out of 3126 female survivors. All of the men had a history of radiation therapy. The 4 men with MBC had estrogen receptors and 3 had progesterone receptors.
CONCLUSIONS: MBC is a rare second malignancy among childhood cancer survivors. Receipt of radiation therapy is a recognized risk factor, but more data about eventual genetic mutations are necessary. Regular screening based only on a history of radiation therapy is not recommended; however, attention must be given in the case of suspicious symptoms.
METHODS AND MATERIALS: We carried out an analysis in a cohort of 7019 five-year survivors of a solid childhood (aged ≤20 years) cancer treated in France before 2001 and followed for an average of 20 years and compared breast cancers occurring in both men and women.
RESULTS: Among the 7019 survivors, 4 out of 3893 male survivors developed breast cancer, compared with 99 out of 3126 female survivors. All of the men had a history of radiation therapy. The 4 men with MBC had estrogen receptors and 3 had progesterone receptors.
CONCLUSIONS: MBC is a rare second malignancy among childhood cancer survivors. Receipt of radiation therapy is a recognized risk factor, but more data about eventual genetic mutations are necessary. Regular screening based only on a history of radiation therapy is not recommended; however, attention must be given in the case of suspicious symptoms.
Предметные рубрики MeSH
AdolescentAdultAgedBreast NeoplasmsBreast Neoplasms, MaleChildChild, PreschoolCohort StudiesFemaleFollow-Up StudiesFranceHumansInfantInfant, NewbornMaleMass ScreeningMiddle AgedNeoplasms, Radiation-InducedNeoplasms, Second PrimaryRadiation DosageRadiotherapyRisk FactorsSex FactorsSurvivorsYoung Adult